Welcome to Imperial History, the podcast where we explore the epic stories of empires that shaped the world, from their triumphant rises to their dramatic falls. I’m your host, Eric Alexander.
Have you ever hear that old saying—”To the victor go the spoils”? Well, imagine if the victors weren’t willing to share. Imagine if they spent years hacking each other to pieces, playing a game of alliances and betrayals so intricate that even the best political strategist today would look at it and say, “Yeah, that’s a bit much.”
That was the world of the Diadochi, the successors of Alexander the Great. Alexander—the man who had stormed across the known world like a force of nature, smashing empires and building his own. But what he left behind wasn’t a stable empire. It was a vacuum. And nature, as they say, abhors a vacuum.
By the year 315 BC, a group of men—once his generals, his friends, his brothers-in-arms—had settled into their new roles as rulers. Antigonus controlled Anatolia and the vast eastern provinces. Cassander had locked down Macedon and much of Greece. Lysimachus had Thrace. And Ptolemy had built his own empire in Egypt, holding Cyrene, Cyprus, and parts of Syria. The world belonged to them now… at least, for the moment.
But power… power is never secure.
Seleucus, one of Antigonus’ officers, had learned this the hard way. He had been governing Babylon—one of the most crucial provinces in the old Persian Empire. Maybe he got a little ahead of himself, maybe he thought he had more freedom than he really did. Because one day, he punished one of Antigonus’ officers without asking permission.
Think about that. Imagine you’re running a region, and you punish one of your subordinates. Sounds reasonable, right? But in this world, in this time, authority wasn’t just about governing. It was about dominance. And by taking action without running it past Antigonus, Seleucus was making a statement—intentional or not.
Antigonus noticed. And he was angry. He sent a message—one that couldn’t have been clearer. If Seleucus thought he could act independently, maybe he’d like to pay for that privilege. Antigonus demanded that Seleucus hand over the province’s income.
Now, what do you do if you’re Seleucus? You’ve got a province, but the most powerful man in the Greek world is staring down at you, demanding your loyalty, your obedience… and now, your money. Seleucus made his choice. He refused.
But refusing Antigonus? That was about as safe as juggling lit torches in an oil-soaked robe. Seleucus wasn’t a fool—he knew what was coming next. So before Antigonus could react, he gathered up fifty horsemen and bolted. His destination? Egypt.
Now, let’s pause here for a second. Because Egypt… Egypt was ruled by Ptolemy. And Ptolemy wasn’t just another one of Alexander’s old generals—he was a player. He had been carving out his own kingdom while the rest of the Diadochi fought among themselves. He had spent the last few years making sure his grip on the Nile was firm, keeping his enemies at bay.
And then, out of nowhere, Seleucus shows up at his doorstep. And this wasn’t just some runaway noble. This was the former ruler of Babylon. A man who had insider knowledge of Antigonus’ power, his army, his ambitions.
That’s when things got interesting. Seleucus wasted no time. He started reaching out—to Cassander in Macedon, to Lysimachus in Thrace. The message was simple:
“Antigonus is too powerful. We either stop him now, or we wait until he comes for us… and he will come for us.”
And maybe they didn’t want to believe it. Maybe they wanted to think Antigonus would be satisfied with his new empire. But deep down, they knew. Power doesn’t rest. Ambition doesn’t stop. So they formed a coalition. On paper, Antigonus had already won. He had the richest land, the biggest army, the most influence. If the Diadochi had just kept to their own domains, kept the peace, he might have consolidated his rule. But that wasn’t going to happen.
Ptolemy, Cassander, Lysimachus—they sent Antigonus a proposition. Call it an ultimatum if you want. They wanted their share.
Phoenicia and Syria? That should go to Ptolemy.
Cappadocia and Lycia? Those should be Cassander’s.
Hellespontine Phrygia? Lysimachus claimed it.
And Babylon—where this whole thing started? Seleucus wanted it back.
It was a bold demand. Effectively half of Antigonus’ territory. Maybe they thought Antigonus would cut his losses and compromise. But they should have known better.
Antigonus wasn’t that kind of man. He refused. And just like that, the uneasy balance between the Diadochi was shattered. In the spring of 314 BC, Antigonus gathered his forces. His army—hardened from years of conquest—was ready to march. His target? The lands of Ptolemy. He set his sights on Syria. And so began the third war of the Diadochi.
Antigonus was no fool. He knew he needed allies. So what does he do? He sends a man named Aristodemus to the Peloponnese—not armed with swords or spears, but with gold. His mission? Buy an army.
But that wasn’t all. Antigonus also made a shrewd political move: he allied with Polyperchon, his former rival during the Second War of the Diadochi, who still held influence in parts of Greece. And in a stroke of propaganda genius, he promised political freedom to the once-independent Greek city-states. That was enough to turn public opinion in his favor—and give Cassander a serious headache.
After securing Syria, Antigonus marched west against Asander, a satrap in Anatolia who had been forced into opposition by Ptolemy. He left his son, Demetrius, behind to hold Syria and Phoenicia, tasking him with challenging Ptolemy and his ambitious general, Seleucus.
Ptolemy saw an opportunity. Syria was now in the hands of Antigonus’ young and untested son. Without hesitation, he struck. Alongside Seleucus, he marched into the Levant with a formidable force: 18,000 infantry and 4,000 cavalry.
Demetrius… Well, Demetrius had confidence. Maybe too much of it. His advisors warned him: “You’re young. They’re veterans. Avoid an all-out battle.” But Demetrius didn’t listen. He wanted glory. He wanted victory.
The armies clashed at Gaza. On paper, Demetrius had a comparable force—but he believed he had an edge: 60 war elephants. His hammer. Massive, unstoppable beasts, bred to smash through enemy lines.
Ptolemy and Seleucus quickly adapted. They placed 3,000 heavy cavalry under their personal command and positioned a specialized anti-elephant corps in front of them. These soldiers had one job: stop the elephants. They carried bows, slings, and, most importantly, anti-elephant devices—spikes linked by chains, designed to trip up the giant beasts and render them useless.
Then, chaos.
The anti-elephant corps did its job. Most of Demetrius’ prized elephants were either captured or killed, throwing his cavalry into disarray. Panic spread. His elite cavalry—his pride and joy—began to fall back. Demetrius tried to hold the line, but it was too late. The Ptolemaic phalanx advanced, and the Antigonid formation crumbled.
Men threw down their weapons. They ran.
It was a disaster.
The losses were staggering: 8,500 men gone—500 dead, 8,000 captured. His elephants? Gone. His reputation? In shambles.
Barely escaping to Tripolis in Phoenicia, Demetrius licked his wounds. But he wasn’t done. Even in defeat, he was already planning his next move. He sent an urgent message to his father, who had just finished crushing Asander’s rebellion.
He needed reinforcements. Fast.
Seleucus wasn’t going to wait for Antigonus. He had played this game before—once ruling Babylonia before being driven out by Antigonus. But now? Antigonus was marching from the far west, his eastern territories exposed. Seleucus saw his opening.
He convinced Ptolemy to let him go, and Ptolemy even gave him a small force—just 1,000 men. Not much, but enough. When Seleucus reached Babylon in May 311 BC, he found a city ready for his return. The people remembered him. The old Macedonian veterans from Carrhae rallied to his side. He walked in, and just like that, he was recognized as ruler.
It was almost too easy.
But there was one problem—Antigonus’ loyalists still held the fortress.
And this is where Seleucus did something… remarkable. He didn’t storm the walls. He didn’t throw his men at the defenses. Instead, he played the long game. He diverted the Euphrates, building a dam, creating an artificial lake. The defenders inside the fortress must have watched in confusion. What’s he doing? What’s the point?
Then, in August, he broke the dam.
A flood wave crashed into the fortress walls, toppling them, sweeping away the defenses. The stronghold was gone. Babylon was his.
But he wasn’t done.
Because Antigonus wasn’t the type to let this slide. His satraps in Media and Aria—Nicanor and Euagoras—were already moving. They brought with them a real army: 10,000 infantry and 7,000 cavalry. A force that could crush Seleucus with sheer numbers alone.
Seleucus? He had just 3,000 infantry and 400 cavalry. That’s it.
And yet, he didn’t run. He didn’t brace for a head-on battle. He waited. He hid his men in the marshes near the Tigris. And when night fell, he attacked.
The Macedonian soldiers in the enemy ranks? They broke. The Iranian troops? They saw which way the wind was blowing and switched sides.
In a single brilliant stroke, Seleucus didn’t just survive—he gained an army.
By November, he was on the move. He marched through the Zagros Mountains, seized Ecbatana—the jewel of Media—then took Susa, the capital of Elam.
He now controlled not just Babylon, but all of southern Iraq and most of Iran.
In just a few months, he had gone from an exiled nobody to a king in all but name.
By the winter of 311 BC, Antigonus had secured a peace agreement with three of his rivals: Cassander in Macedonia, Ptolemy in Egypt, and Lysimachus in Thrace.
As Antigonus concluded this treaty, urgent news reached him from the east. Seleucus had not only reclaimed Babylon but had surged through the eastern satrapies, subduing vast territories that had once belonged to Antigonus. The lands of Persia, Media, and beyond had fallen to him. Seleucus had moved with stunning speed, and his control over the east was now a reality.
Antigonus had little choice but to respond. He could not afford to lose the eastern half of Alexander’s empire. However, instead of marching himself, he dispatched his son, Demetrius to reassert Antigonid rule over Babylon.
Demetrius arrived in the spring of 310 BC. Perhaps he believed that the mere sight of his army would be enough to bring the city back under Antigonid control. He entered Babylon and, for a brief moment, must have thought the campaign was won. The city had been taken, its gates open to him.
But war is rarely so simple.
Seleucus’ forces were still active, and they were well-prepared. They counterattacked swiftly, and Demetrius found himself outmaneuvered. He lacked the manpower and resources to sustain a prolonged engagement, and within a short time, he was forced to withdraw from the city entirely, retreating back to Syria.
This was not the end of the struggle. Antigonus himself, unwilling to accept such a loss, personally led a second campaign later that year. By the autumn of 310 BC, he had marched east and once again entered Babylon. He had succeeded where his son had failed.
Yet, as Demetrius had learned, taking Babylon was one thing—keeping it was another.
Seleucus had mastered the art of asymmetric warfare. He allowed Antigonus to occupy the city but kept up a relentless pressure through guerrilla-style engagements and strategic counterattacks. Antigonus found himself facing an elusive enemy, one that would not be drawn into a conventional battle on his terms. By March of 309 BC, he could no longer sustain his position in the region. He was forced to abandon Babylon, just as Demetrius had.
The final confrontation came later that year, at the Battle of the 25th of Abu (a Babylonian month corresponding to late summer). This time, Seleucus decisively defeated Antigonus’ forces. The war in the east was over. Antigonus had no choice but to acknowledge Seleucus as the rightful ruler of Babylon and the eastern provinces.
With this, the Third War of the Diadochi had effectively concluded. But in the west, an event of even greater significance was about to take place—one that should have reshaped the entire power structure of the empire. And yet, it barely caused a ripple among the men who were effectively kings in all but name.
By 309 BC, Alexander IV, the only legitimate son of Alexander the Great, had reached the age of fourteen. In Macedonian tradition, this was a moment of profound significance. Fourteen was the recognized age of manhood, the point at which a young prince could be declared ruler in his own right. The long period of regency was supposed to end.
In theory, Alexander IV should have stepped forward as the true king of Macedonia and the heir to the entire empire. The peace agreements signed by the Diadochi had explicitly recognized his rights. Cassander, who had served as the regent in Macedonia, was supposed to hand power over when the boy came of age.
But power, once seized, is rarely relinquished voluntarily.
Cassander had no intention of stepping aside. He had spent too many years consolidating his position in Greece and Macedonia, and Alexander IV—son of the legendary conqueror—was a threat he could not allow to exist.
And so, with quiet efficiency, Cassander had the young king and his mother, Roxana, poisoned. The last legitimate blood heir of Alexander the Great was dead.
With the murder of Alexander IV, the Argead dynasty—the ruling house of Macedonia for centuries—came to an end. The dynasty that had produced Philip II, the unifier of Greece, and Alexander the Great, the conqueror of Persia, was extinguished in an act of political expediency.
The reaction from the other Diadochi was telling. There was no great outcry. No war of retribution. No attempt to avenge the young king’s death. The men who had once sworn allegiance to Alexander seemed indifferent.
Why? Because Alexander IV was an obstacle. His continued existence threatened the new reality that these men had built. Ptolemy in Egypt, Seleucus in the east, Lysimachus in Thrace, Antigonus in Asia—all of them had taken steps toward making themselves kings in their own right. If Alexander’s legitimate heir had lived, it would have undermined the very foundations of their power.
Even Polyperchon, one of the few remaining old guard loyal to the Argeads, recognized the shifting tides. He attempted to rally support around another potential heir—Heracles, the illegitimate son of Alexander the Great by a Persian noblewoman. But Cassander, ever pragmatic, simply bribed Polyperchon. The old general accepted Cassander’s offer, murdered Heracles, and was rewarded with an alliance and the restoration of his Macedonian estates.
And that was that.
The Argead dynasty was gone.
The Diadochi no longer needed the pretense of ruling in Alexander’s name. The dream of a unified empire had died with his son.